National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. doi: 10.1016/j.cell.2020.05.035.

Here, we use mammalian native elongating transcript sequencing (mNET-seq) to examine Pol II behavior during viral infection. This site needs JavaScript to work properly.
OX1 3PU, © 2020 The University of Oxford Department of Physics. 2020 Jun 25;181(7):1502-1517.e23. He … 503 Ergebnisse zu David Bauer: Actor, University, Arena, Department, Netzwerk, TSV, Author, Calgary, Chief Investment Officer DNA catenation has been implicated in both sister chromatid cohesion and chromosome condensation, but has never been observed directly.

Print 2017 Sep 1. We show that different IAV genome segments acquire distinct RNA conformations and form both intra- and intersegment RNA interactions inside influenza virions. Article plus Supplemental Information, Influenza Virus Mounts a Two-Pronged Attack on Host RNA Polymerase II Transcription, Xrn2 accelerates termination by RNA polymerase II, which is underpinned by CPSF73 activity, Document S1.
DNA catenation has been implicated in both sister chromatid cohesion and chromosome condensation, but has never been observed directly. Print 2017 Jun 1. by the Fair Credit Reporting Act (FCRA). 40% of these people are married, and 60% are single. Get the latest research from NIH: https://www.nih.gov/coronavirus. David’s education is listed on their profile. The authors declare no competing financial interests. By directly staining DNA, we observe that DNA catenation between sister chromatids (separated by fluid flow) is composed of distinct fibres of DNA concentrated at the centromeres. Inter-segment RNA interactions drive…. Figure 4 |. The structure of viral RNA is believed to play a role in assembling the different vRNPs into budding virions1-8 and in directing reassortment between IAVs9. Earlier studies of this consensus lac promoter derivative identified a strong pause at ITC6 27, ... During transcription elongation, backtracking of RNAP is seen especially at transcript pause sites 1,11,12,18 .

Combining sample expansion and light sheet microscopy for the volumetric imaging of virus-infected cells with super-resolution. View David Bauer’s profile on LinkedIn, the world's largest professional community. OX1 3PU, © 2020 The University of Oxford Department of Physics. ... As mentioned earlier, mRNA 3′ processing is required for RNAPII transcription termination [1][2][3][4] . The IAV genome consists of eight single-stranded viral RNA segments contained in separate viral ribonucleoprotein (vRNP) complexes that are packaged together into a single virus particle. eCollection 2020. The project partners have discovered, created and developed a huge body of insights into nucleic acid ana... We show how a bird's-eye view of genomic structure can be obtained at ∼1-kb resolution from long (∼2 Mb) DNA molecules extracted from whole chromosomes in a nanofluidic laboratory-on-a-chip. ... To monitor the kinetics of transcription initiation at the single-molecule level, we developed a Förster resonance energy transfer (FRET) sensor with fluorophore-labeled consensus lac promoter for realtime imaging of individual transcription-engaged RNAP-promoter complexes. Nature Microbiology Nature Publishing Group 3 (2018) 1234–1242-, AJW te Velthuis, JC Long, DLV Bauer, RLY Fan, H-L Yen, J Sharps, JY Siegers, MJ Killip, H French, MJ Oliva-Martín, RE Randall, E de Wit, D van Riel, LLM Poon, E Fodor. doi: 10.1128/JVI.00195-17. These stresses include heat shock, osmotic stress, hypoxia, influenza A virus (IAV) infection, herpes simplex virus 1 (HSV-1) infection, senescence, and cancer. The structure of the influenza A virus genome, Pausing controls branching between productive and non-productive pathways during initial transcription in bacteria, Mini viral RNAs act as innate immune agonists during influenza virus infection, Table S1. 2015 Jun;32(6):1519-32. doi: 10.1093/molbev/msv044. Epub 2020 Jun 18. Reassortment between established human IAVs and IAVs harboured in the animal reservoir can lead to the emergence of pandemic influenza strains to which there is little pre-existing immunity in the human population10,11. 7 Sir William Dunn School of Pathology, University of Oxford, Oxford, UK. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. The molecular processes that determine the outcome of influenza virus infection in humans are multifactorial and involve a complex interplay between host, viral and bacterial factors1. We use an improved single-molecule denaturation mapping approach to detect repetitive elements and known as well as unique structural variation. The molecular processes that determine the outcome of influenza virus infection in humans are multifactorial and involve a complex interplay between host, viral and bacterial factors1. Mascheroni L, Scherer KM, Manton JD, Ward E, Dibben O, Kaminski CF. Phipps KL, Marshall N, Tao H, Danzy S, Onuoha N, Steel J, Lowen AC. Recent studies have demonstrated that cellular stress can disrupt normal transcription termination, leading to aberrant transcription of intergenic regions downstream of canonical termination sites (termed readthrough transcription or downstream of gene [DoG] transcription) through an unknown mechanism (pictured in Fig. We use our detailed map of IAV genome structure to provide direct evidence for how intersegment RNA interactions drive vRNP cosegregation during reassortment between different IAV strains. The IAV genome consists of eight RNA segments contained in separate viral ribonucleoprotein complexes (vRNPs) that are packaged together into a single virus particle 1,2 .

NIH Figure 2 |. Figure 1 |. Inter-segment RNA interactions in…. J Virol.

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