Discover our research outputs and cite our work. 2020 Sep 18;48(16):8848-8869. doi: 10.1093/nar/gkaa666. Comparison of global microRNA, and protein expression reveals p53-dependent pathways in cancer. (A) Schematic overview of Mutex algorithm…, Figure 7.. Development of a prognostic mutant…. Identification of Small Molecules that Modulate Mutant p53 Condensation. HHS Comparison of global RNA expression…. An analysis of five data platforms in 10,225 patient samples from 32 cancers reported by The Cancer Genome Atlas (TCGA) enables comprehensive assessment of p53 pathway involvement in these cancers.

Donehower LA, Soussi T, Korkut A, Liu Y, Schultz A, Cardenas M, Li X, Babur O, Hsu TK, Lichtarge O, Weinstein JN, Akbani R, Wheeler DA. EBioMedicine.

An analysis of five data platforms in 10,225 patient samples from 32 cancers reported by The Cancer Genome Atlas (TCGA) enables comprehensive assessment of p53 pathway involvement in these cancers. TP53 mutations are associated with enhanced chromosomal instability, including increased amplification of oncogenes and deep deletion of tumor suppressor genes. NIH Epub 2020 Jul 16. Figure 5.. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Comparison of global microRNA, and…. Thus, TP53 mutation has profound effects on tumor cell genomic structure, expression, and clinical outlook. Figure 3.. TP53 mutation is correlated with…. TP53 mutational landscape of metastatic head and neck cancer reveals patterns of mutation selection. Lawrence Donehower, Thierry Soussi, Anil Korkut, Yuexin Liu, Andre Schultz, Maria Cardenas, Xubin Li, Ozgun Babur, Teng-Kuei Hsu, Olivier Lichtarge, John Weinstein, Rehan Akbani and David Wheeler, Full USA.gov. To submit an update or takedown request for this paper, please submit an Update/Correction/Removal

An analysis of five data platforms in 10,225 patient samples from 32 cancers reported by The Cancer Genome Atlas (TCGA) enables comprehensive assessment of p53 pathway involvement in these cancers. 2020 Sep 1;80(17):3732-3744. doi: 10.1158/0008-5472.CAN-20-1390. Cell Rep. 2019 Sep 10;28(11):3010. doi: 10.1016/j.celrep.2019.08.061. Figure 7.. Development of a prognostic mutant TP53 signature. 2020 Jun 30;6(8):FSO610.

Tumors with TP53 mutations differ from their non-mutated counterparts in RNA, miRNA, and protein expression patterns, with mutant TP53 tumors displaying enhanced expression of cell cycle progression genes and proteins.

Figure 1.. TP53 mutation profile in the…, Figure 1.. TP53 mutation profile in the TCGA dataset is similar to that of current…, Figure 2.. Inactivation of both alleles occurs…. 2017 Oct 3;18(10):775-782. doi: 10.1080/15384047.2017.1373212. TP53 mutation effects analyzed by five data platforms in 32 cancers/10,225 patients, More than 91% of cancers with TP53 mutations show loss of both functional TP53 alleles, TP53 mutation affects genomic stability, global RNA, miRNA, and protein expression, Mutant p53 RNA expression signature helps prognostic predictions in 11 cancer types. NLM Tumor suppressor p53: from engaging DNA to target gene regulation. and Jisc. 2018 Apr 10;419:96-102. doi: 10.1016/j.canlet.2018.01.013.

 |  Figure 5.. Copyright © 2020 Elsevier B.V. or its licensors or contributors. COVID-19 is an emerging, rapidly evolving situation. This site needs JavaScript to work properly. Donehower et al. Thus, TP53 mutation has profound effects on tumor cell genomic structure, expression, and clinical outlook. The TP53 tumor suppressor gene is frequently mutated in human cancers. The TP53 tumor suppressor gene is frequently mutated in human cancers. Cancer Lett. PanCanAtlas; TCGA; TP53; TP53 mutation; The Cancer Genome Atlas; chromosomal instability; p53; p53 signaling pathway; p53 signature; p53 targets. See this image and copyright information in PMC. Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas.

Tumors with TP53 mutations differ from their non-mutated counterparts in RNA, miRNA, and protein expression patterns, with mutant TP53 tumors displaying enhanced expression of cell cycle progression genes and proteins. G Baramiya M, Baranov E, Saburina I, Salnikov L. Future Sci OA. We use cookies to help provide and enhance our service and tailor content and ads. Figure 4.. Figure 4..

Donehower et al.

Comparison of global RNA expression reveals p53-dependent pathways in cancer. Cancer Res. A mutant TP53 RNA expression signature shows significant correlation with reduced survival in 11 cancer types. Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas Lawrence A. Donehower, Thierry Soussi, Anil Korkut, Yuexin Liu, Andre Schultz, Maria Cardenas, Xubin Li, Ozgun Babur, Teng-Kuei Hsu, Olivier Lichtarge, John N. Weinstein, Rehan Akbani, and David A. Wheeler The authors declare no competing interests. Effects of TP53 mutational status on gene expression patterns across 10 human cancer types. More than 91% of TP53-mutant cancers exhibit second allele loss by mutation, chromosomal deletion, or copy-neutral loss of heterozygosity.

Get the latest public health information from CDC: https://www.coronavirus.gov. From cancer to rejuvenation: incomplete regeneration as the missing link (part II: rejuvenation circle). Mol Genet Genomics. Friend or Foe: MicroRNAs in the p53 network.

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Download : Download high-res image (219KB)Download : Download full-size image.  |  Copyright © 2019 The Author(s). 2017 Jan 3;8(1):624-643. doi: 10.18632/oncotarget.13483. For all LGG, RNA expression of the four genes comprising the mutant p53 signature (. Keywords: Erratum for Cell Rep. 2019 Jul 30;28 (5):1370-1384.e5. Lemos C, Schulze L, Weiske J, Meyer H, Braeuer N, Barak N, Eberspächer U, Werbeck N, Stresemann C, Lange M, Lesche R, Zablowsky N, Juenemann K, Kamburov A, Luh LM, Leissing TM, Mortier J, Steckel M, Steuber H, Eis K, Eheim A, Steigemann P. iScience. Epub 2014 Jan 29. Clipboard, Search History, and several other advanced features are temporarily unavailable.

An analysis of five data platforms in 10,225 patient samples from 32 cancers reported by The Cancer Genome Atlas (TCGA) enables comprehensive assessment of p53 pathway involvement in these cancers. More than 91% of TP53-mutant cancers exhibit second allele loss by mutation, chromosomal deletion, or copy-neutral loss of heterozygosity. Thus, TP53 mutation has profound effects on tumor cell genomic structure, expression, and clinical outlook. Figure 6.. Genomic alterations mutually exclusive with…. An analysis of five data platforms in 10,225 patient samples from 32 cancers reported by The Cancer Genome Atlas (TCGA) enables comprehensive assessment of p53 pathway involvement in these cancers. More than 91% of TP53 -mutant cancers exhibit second allele loss by mutation, chromosomal deletion, or copy-neutral loss of heterozygosity. The TP53 tumor suppressor gene is frequently mutated in human cancers. Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas. Parikh N, Hilsenbeck S, Creighton CJ, Dayaram T, Shuck R, Shinbrot E, Xi L, Gibbs RA, Wheeler DA, Donehower LA.

An analysis of five data platforms in 10,225 patient samples from 32 cancers reported by The Cancer Genome Atlas (TCGA) enables comprehensive assessment of p53 pathway involvement in these cancers. citation, Archive Ouverte en Sciences de l'Information et de la Communication, Update/Correction/Removal Request.

An analysis of five data platforms in 10,225 patient samples from 32 cancers reported by The Cancer Genome Atlas (TCGA) enables comprehensive assessment of p53 pathway involvement in these cancers.

Please enable it to take advantage of the complete set of features! ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. https://doi.org/10.1016/j.celrep.2019.07.001. (B) Pathway representation of mutually exclusive partners of, (A) Lower grade glioma (LGG) stratified by mutant p53 expression signature correlates with a number of clinical and molecular parameters. 2018 Jun;293(3):737-746. doi: 10.1007/s00438-018-1416-7. Epub 2018 Jan 12.



TP53 mutations, expression and interaction networks in human cancers. More than 91% of TP53-mutant cancers exhibit second allele loss by mutation, chromosomal deletion, or copy-neutral loss of heterozygosity. A mutant TP53 RNA expression signature shows significant correlation with reduced survival in 11 cancer types. Online ahead of print.

By continuing you agree to the use of cookies. performed a comprehensive analysis of the effects of TP53 gene mutation in 32 cancer types and 10,225 patients from The Cancer Genome Atlas (TCGA). the Open University performed a comprehensive analysis of the effects of TP53 gene mutation in 32 cancer types and 10,225 patients from The Cancer Genome Atlas (TCGA). An analysis of five data platforms in 10,225 patient samples from 32 cancers reported by The Cancer Genome Atlas (TCGA) enables comprehensive assessment of p53 pathway involvement in these cancers… Epub 2017 Sep 8. Epub 2020 Jul 30. Donehower LA, Soussi T, Korkut A, Liu Y, Schultz A, Cardenas M, Li X, Babur O, Hsu TK, Lichtarge O, Weinstein JN, Akbani R, Wheeler DA.  | 

2020 Aug;58:102905. doi: 10.1016/j.ebiom.2020.102905. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error, (A) p53 functional analyses in some TCGA tumors with two, (A) Genomic profile aggregated from copy number data of all TCGA tumors shows that frequent amplifications and deep deletions occur significantly more in MUT, (A) The most significantly upregulated gene RNAs in wildtype, (A) Schematic overview of Mutex algorithm for determining gene mutual exclusivity (see Methods).
Figure 3.. TP53 mutation is correlated with increased chromosomal instability.

Expression of SESN1, UHRF1BP1, and miR-377-3p as prognostic markers in mutated TP53 squamous cell carcinoma of the head and neck. Data synthesized from five different analysis platforms show how mutant TP53 increases genomic instability and induces major pathway signaling changes in cancer cells. Published by Elsevier Inc. All rights reserved. Data synthesized from five different analysis platforms show how mutant TP53 increases genomic instability and induces major pathway signaling changes in cancer cells. More than 91% of TP53-mutant cancers exhibit second allele loss by mutation, chromosomal deletion, or copy-neutral loss of heterozygosity. More than 91% of TP53-mutant cancers exhibit second allele loss by mutation, chromosomal deletion, or copy-neutral loss of heterozygosity.

TP53 mutations are associated with enhanced chromosomal instability, including increased amplification of oncogenes and deep deletion of tumor suppressor genes. Epub 2018 Jan 9. doi: 10.2144/fsoa-2020-0085. Figure 2.. Inactivation of both alleles occurs in most TCGA cancers with TP53 mutations. Sammons MA, Nguyen TT, McDade SS, Fischer M. Nucleic Acids Res.

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